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Document Details
Document Type
:
Article In Journal
Document Title
:
Morphological and metabolic shifts of Yarrowia lipolytica induced by alteration of the dissolved oxygen concentration in the growth environment
Morphological and metabolic shifts of Yarrowia lipolytica induced by alteration of the dissolved oxygen concentration in the growth environment
Document Language
:
English
Abstract
:
Yarrowia lipolytica, an ascomycete with biotechnological potential, is able to form either yeast cells or hyphae and pseudohyphae in response to environmental conditions. This study shows that the morphology of Y. lipolytica, cultivated in batch cultures on hydrophilic (glucose and glycerol) and hydrophobic (olive oil) media, was not affected by the nature of the carbon source, nor by the nature or the concentration of the nitrogen source. By contrast, dissolved oxygen concentration (DOC) should be considered as the major factor affecting yeast morphology. Specifically, when growth occurred at low or zero DOC the mycelial and/or pseudomycelial forms predominated over the yeast form independently of the carbon and nitrogen sources used. Experimental data obtained from a continuous culture of Y. lipolytica on glycerol, being used as carbon and energy source, demonstrated that the mycelium-to-yeast form transition occurs when DOC increases from 0.1 to 1.5 mg l(-1). DOC also affected the yeast physiology, as the activity of enzymes implicated in lipid biosynthesis (i.e. ATP-citrate lyase, malic enzyme) was upregulated at high DOC whereas the activity of enzymes implicated in glycerol assimilation (such as glycerol dehydrogenase and kinase) remained fundamentally unaffected in the cell-free extract.
ISSN
:
1350-0872
Journal Name
:
MICROBIOLOGY-SGM
Volume
:
160
Issue Number
:
4
Publishing Year
:
1435 AH
2014 AD
Article Type
:
Article
Added Date
:
Tuesday, August 1, 2017
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
Stamatia Bellou
Bellou, Stamatia
Researcher
Anna Makri
Makri, Anna
Researcher
Irene-Eva Triantaphyllidou
Triantaphyllidou, Irene-Eva
Researcher
Seraphim Papanikolaou
Papanikolaou, Seraphim
Researcher
George Aggelis
Aggelis, George
Researcher
Files
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Type
Description
42388.pdf
pdf
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