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Document Type |
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Article In Journal |
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Document Title |
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Synthesis of Substituted Thioureas and Their Sulfur Heterocyclic Systems of p-Amino Acid as Antimycobacterial Agents Synthesis of Substituted Thioureas and Their Sulfur Heterocyclic Systems of p-Amino Acid as Antimycobacterial Agents |
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Document Language |
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English |
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Abstract |
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A series of new N,N'-substituted thioureas (2, 6, and 8) and their sulfur heterocycles as thiobarbituric acids (3, 4, and 7), 2-thioxothiazoliodin-4-one (10), thiozolidin-4-one (11), 1,2,4-triazol-5thione (14), and 1,3,4-thiadiazole (15) of p-Amino salicylic acid (PAS) have been synthesized from treatment with dithiocarbazinate (1, 5 and 12) followed by heterocyclization with dimenthyl malonate, chloroacetic acid, and/or trifluoroacetic anhydride. The structures of the newly synthesized compounds were substantiated with IR, H-1, and C-13 NMR spectral data elementary microanalysis. The in vitro antitubercular activity of synthesized compounds against M. tuberculosis strain H37Rv showed moderate-to-good activity. |
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ISSN |
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2090-9063 |
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Journal Name |
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JOURNAL OF CHEMISTRY |
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Volume |
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1 |
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Issue Number |
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1 |
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Publishing Year |
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1434 AH
2013 AD |
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Article Type |
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Article |
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Added Date |
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Thursday, July 20, 2017 |
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Researchers
| M Makki | Makki, M | Researcher | | |
| R Abdel-Rahman | Abdel-Rahman, R | Researcher | | |
| H Faidallah | Faidallah, H | Researcher | | |
| K Khan | Khan, K | Researcher | | |
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