Document Details

Document Type : Article In Journal 
Document Title :
Spectroscopic Studies of the Complexation of Iodine with Antihistamine Drugs in Solvents of Varying Relative Permittivity
Spectroscopic Studies of the Complexation of Iodine with Antihistamine Drugs in Solvents of Varying Relative Permittivity
 
Document Language : English 
Abstract : The interaction of oxatomide (OXA), azacyclonol (AZA) and chloropheniramine (ClPA) antihistamine drugs with iodine was studied spectrophotometrically in different solvents and at three different temperatures. The electronic, FT-IR, far-IR, and mass spectra of the resulting charge-transfer (CT) complexes were recorded, in addition to thermal analysis. The results obtained show that the stoichiometries of the reactions are all 1:1. The observed time dependence of the CT band and subsequent formation of in solution were related to the slow transformation of the initially formed 1:1 (donor: I-2) outer complex to an inner complex (electron donor-acceptor), followed by a fast reaction of the inner complex with iodine to form a triiodide ion. The characteristic strong absorptions of are observed around 360 nm. The CT-complexes have the formulae [(OXA)I](+) , [(AZA)I](+) and [(ClPA)I](+) . The formation constants (K), molar absorption coefficients (epsilon (CT)), and thermodynamic parameters Delta H (#), Delta S (#) and Delta G (#) of these interaction have been determined and discussed. 
ISSN : 0095-9782 
Journal Name : JOURNAL OF SOLUTION CHEMISTRY 
Volume : 41 
Issue Number : 12 
Publishing Year : 1433 AH
2012 AD 
Article Type : Article 
Added Date : Monday, July 10, 2017 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
M PandeeswaranPandeeswaran, M Researcher  
E El-MossalamyEl-Mossalamy, E Researcher  
P ElangoElango, P Researcher  

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