Document Details
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Document Type |
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Thesis |
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Document Title |
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Pre and Postnatal study of the developing kidney and Testes of the Albino Rat under the effect of antibiotic"Maxipime" (Cefepime hydrochlorid) دراسة نمو الكلية والخصية في الجرذان البيضاء تحت تأثير المضاد الحيوي "ماكسيبيم" (سيفيبيم هيدروكلوريد) قبل وبعد الولادة |
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Subject |
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Mice |
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Document Language |
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Arabic |
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Abstract |
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In this study ( 83) mature albino rat were used ,(55) were female and (28) were male for investigate the effect of administration of Maxipame intraperitonealy by a dose (0.07 mg/rat) and the developing prenatal (20-gestational) days old rat and postnatal (7,14,21,30,45) days old .The drug was injected in the treated group at (8-14) days of gestation ,and at (1-7) days after delivery to the breast feeding group study the effect of the drug through placental and milk barriers. The total generation was (205). The morphological studies included malformation effects on , weights and heights and the histological studies by using different staines were done on all control and both treated groups of embryos and infants .The studies revealed that at the prenatal group age 20-gestational days old the drug induced congestion under skin, swelling at abdominal part .As age advanced in the postnatal treated groups, hair did not grow in some areas of the head in some groups. Significant decrease in weights had been appeared in the treated groups and the most affected one were (postT30) treated gestational days old and the breast feeding groups at (post F7, and post F45). There were significant decrease in height at breast feeding groups at (post F21, Post F30, postF45). By light microscope ,the tests showed small sized spermatocytes, decrease in the average of cell division inside the semineferous follicles, decrease the density of primary spermatocytes accompanied by secondary spermatocytes hardly seen . Regarding to kidney, there were delay growth and development such as decrease of thick of the renal capsule, decrease in number of glomerulus, appearance of shrunked or atrophied renal corpuscles containing cellular degeneration with detached of the outer layer of Bowman's capsule, dilatation of urinary space. The tubules are collapsed.. Also, there was an increase in the interstitial tissue edema . There were degeneration of the cells of the two selected organs and a necrotic tissue with pyknotice or, karyolysis nuclei and vacuolated cytoplasm. It was detected from this study that, the placental barrier and the milk barrier allowed the passage of the drug to the embryos and fetouses. We advised the pregnant mother to avoid intake of drugs during gestation and breast feeding period and in case of medication intake it should yield to medical supervision. |
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Supervisor |
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Badria Fathy Ahmed Abd-El-Majid |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1430 AH
2009 AD |
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Number Of Pages |
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269 |
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Added Date |
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Tuesday, September 3, 2013 |
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Researchers
| فاطمة عياش جابر | Jabber, Fatmah Ayash | Investigator | Master | |
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