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Faculty of Sciences
Document Details
Document Type
:
Article In Journal
Document Title
:
Mammal toxicity and mutagenicity assessment of the methanol extract of the molluscicidal plant Euphorbia schimperiana
Mammal toxicity and mutagenicity assessment of the methanol extract of the molluscicidal plant Euphorbia schimperiana
Subject
:
Biological
Document Language
:
English
Abstract
:
In this study, the toxic and mutagenic effects of Euphorbia schimperiana-methanol extract were investigated in Swiss albino mice of both sexes. In the course of a toxicological evaluation of this extract and prior to field applications, selected acute toxicity tests (oral, dermal, skin and eye irritation) were firstly determined. Then, three doses of acute oral (maximum, half maximum and double maximum) were chosen for the assessment of mutagenicity using the micronucleus test. While, the tested extract was slightly toxic non, irritant to the skin and moderately irritant to the ocular tissue it significantly increased the frequency of micro-nuclei particularly at the doubly maximum dose in both sexes. In conclusion, the results indicated that the Euphorbia schimperiana-methanol extract has slightly toxic effect. But has a potent mutagenic effect in mice.
ISSN
:
1028-8880
Journal Name
:
Pakistan Journal of Biological Sciences
Volume
:
9
Issue Number
:
10
Publishing Year
:
1427 AH
2006 AD
Article Type
:
Article
Added Date
:
Wednesday, December 28, 2011
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
Ekram S Ahmed
Ahmed, Ekram S
Researcher
Doctorate
ناجية عبدالخالق الزنبقي
Al-Zanbagi, Najia A
Researcher
Doctorate
nalzanbagi@gmail.com
Files
File Name
Type
Description
31845.pdf
pdf
Abstract
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